The Binding of Isaac: Rebirth — best settings

On the ASUS ROG Ally X, The Binding of Isaac: Rebirth is tuned to run at 40 FPS with the TDP capped at 9W, rendering at 720p with RSR Quality. Its native 1080p IPS display refreshes at 120Hz, and The Binding of Isaac: Rebirth runs natively on Windows. These settings are compiled from 5 sources and 80% corroborated across independent guides. Verified current as of June 2026.

About the game

Overwhelmingly Positive

The Binding of Isaac: Rebirth is a randomly generated action RPG shooter with heavy Rogue-like elements. Following Isaac on his journey players will find bizarre treasures that change Isaac’s form giving him super human abilities and enabling him to fight off droves of mysterious creatures, discover secrets and fight his way to safety.

Don't own it yet? Get The Binding of Isaac: Rebirth
The Binding of Isaac: Rebirth trailer

Recommended config

Verified Jun 2026 80% corroborated
Device
Steam Deck OLEDASUS ROG Ally X
Setting type
Balanced Batterysoon Max Qualitysoon
40FPS
Framerate
9W
Power (TDP)
720p
Resolution
RSR Quality
Upscaling
⬇ Download settings cheat-sheet (.txt)

Get settings updates

A short email when we refresh these settings or add games. No spam.

In-game settings

Tap a row to check it off · compiled and verified from 5 sources · single-source value

Other settings

Frequently asked questions

Can The Binding of Isaac: Rebirth run well on the ASUS ROG Ally X?

The Binding of Isaac: Rebirth is playable at 40 FPS on the ASUS ROG Ally X with these settings. These values are 80% corroborated across independent guides.

What FPS does The Binding of Isaac: Rebirth hit on the ASUS ROG Ally X?

With these settings The Binding of Isaac: Rebirth targets 40 FPS on the ASUS ROG Ally X.

What TDP should I use for The Binding of Isaac: Rebirth on the ASUS ROG Ally X?

Cap the TDP at 9W for The Binding of Isaac: Rebirth on the ASUS ROG Ally X.

What resolution and upscaling are best for The Binding of Isaac: Rebirth on the ASUS ROG Ally X?

Render The Binding of Isaac: Rebirth at 720p with RSR Quality on the ASUS ROG Ally X.

What's different about running The Binding of Isaac: Rebirth on the ASUS ROG Ally X?

The ROG Ally X has a native 1080p IPS screen at 120Hz and runs natively on Windows, so these settings are tuned for that panel.

How do the The Binding of Isaac: Rebirth settings differ on the ASUS ROG Ally X vs the Steam Deck OLED?

On the ASUS ROG Ally X this guide differs from the Steam Deck OLED on frame rate (40 FPS vs 60 FPS), TDP (9W vs 5W), resolution (720p vs 1200x800).

Are these The Binding of Isaac: Rebirth settings verified?

These settings are compiled from 5 sources, 80% corroborated, last verified Jun 2026.

You might also like

The Binding of Isaac

The Binding of Isaac

Best price →
Dishonored

Dishonored

Best price →
Murdered: Soul Suspect

Murdered: Soul Suspect

Best price →
Singularity

Singularity

Best price →
Deus Ex: Mankind Divided

Deus Ex: Mankind Divided

Best price →
BioShock 2

BioShock 2

Best price →
Dishonored 2

Dishonored 2

Best price →
The Legend of Zelda: The Minish Cap

The Legend of Zelda: The Minish Cap

Best price →
The Vanishing of Ethan Carter

The Vanishing of Ethan Carter

Best price →

More games tuned for ASUS ROG Ally X

ASUS ROG Ally X vs Steam Deck OLED

On the ASUS ROG Ally X, The Binding of Isaac: Rebirth runs frame rate 40 FPS (vs 60 FPS on the Steam Deck OLED), TDP 9W (vs 5W on the Steam Deck OLED), resolution 720p (vs 1200x800 on the Steam Deck OLED).

ASUS ROG Ally X-specific tweaks: Memory Assigned to GPU to 8GB or higher, 120Hz refresh rate, VRR Enabled, Radeon Chill Enabled, CPU Boost Off, Disable Windows animations and transparency effects, VSync=0 in Options.ini, MaxRenderScale=1 in Options.ini.

Explore more